Intrinsic regulation

Posttranscriptional Regulation of Intrinsic Plasticity

Intrinsic regulation of enteroendocrine fate by Numb.

How terminal cell fates are specified in dynamically renewing adult tissues is not well understood. Here we explore terminal cell fate establishment during homeostasis using the enteroendocrine cells (EEs) of the adult Drosophila midgut as a paradigm. Our data argue against the existence of local feedback signals, and we identify Numb as an intrinsic regulator of EE fate. Our data further indic...

Intrinsic Regulation of Skeletal Muscle Blood Flow.

• The genesis of intrinsic vascular smooth muscle activity and its role in the local control of tissue blood flow has been the source of considerable controversy, particularly in regard to the mechanism underlying autoregulation of blood flow. The phenomenon of autoregulation has been reported for several vascular beds including kidney, intestine,' 4 brain, and heart. A number of investigators ...

Defining cooperativity in gene regulation locally through intrinsic noise.

Regulatory networks in cells may comprise a variety of types of molecular interactions. The most basic are pairwise interactions, in which one species controls the behaviour of another (e.g. a transcription factor activates or represses a gene). Higher-order interactions, while more subtle, may be important for determining the function of networks. Here, the authors systematically expand a simp...

Intrinsic and Extrinsic Regulation of Innate Immune Receptors

Pattern recognition receptors (PRRs) in innate immune cells play a pivotal role in the first line of host defense system. PRRs recognize pathogen-associated molecular patterns (PAMPs) or danger-associated molecular patterns (DAMPs) to initiate and regulate innate and adaptive immune responses. PRRs include Toll-like receptors (TLRs), RIG-I-like receptors (RLRs) and NOD-like receptors (NLRs), wh...